Arducam MEGA 5mp - Pi Zero 2 w

I need to control the Arducam MEGA through python on the Pi Zero 2 w. Is that possible? I cannot seem to find any examples/guides on this.

I need to be able to trigger autofocus and to capture an image and save on a USB drive connected to the Pi. I am guessing this would be a common use case, but I cannot find information about controlling the camera over SPI through Python.